First Nonphosphorylated Inhibitors of Phosphoglucose Isomerase Identified by Chemical Library Screening
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چکیده
منابع مشابه
Tankyrase 1 Inhibitors with Drug-like Properties Identified by Screening a DNA-Encoded Chemical Library.
We describe the synthesis and screening of a DNA-encoded chemical library containing 76230 compounds. In this library, sets of amines and carboxylic acids are directly linked producing encoded compounds with compact structures and drug-like properties. Affinity screening of this library yielded inhibitors of the potential pharmaceutical target tankyrase 1, a poly(ADP-ribose) polymerase. These c...
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ژورنال
عنوان ژورنال: SLAS DISCOVERY: Advancing the Science of Drug Discovery
سال: 2018
ISSN: 2472-5552,2472-5560
DOI: 10.1177/2472555218787468